Pharmacological action Dovonex Cream:
Dovonex Cream An analogue of the active metabolite of natural vitamin D3. Causes a dose-dependent inhibition of proliferation of keratinocytes and accelerates their morphological differentiation. Has little effect on Ca2 + exchange in the body (from the experimental data at 100-200 times less than calcitriol). The effect occurs within 1-3 weeks.
Indications Dovonex Cream:
Psoriasis vulgaris (including the scalp) in fixed and regressing stages.
Contraindications Dovonex Cream:
Hypersensitivity, psoriasis of the scalp in the acute phase, pregnancy, lactation. Hypercalcemia, hypercalciuria (including disposition), hypervitaminosis of vitamin-D, nefrourolitiaz history, the age of 18 years, older age (65 years).
Side effects Dovonex Cream:
Dermatitis (itching, swelling and redness of the skin) – in 10-15% of cases for ointments and creams, and 1-5% for a solution, skin rash – in 1-10% of cases for ointments and creams, and 11% for a solution, transient burning , skin irritation, itchy skin – 20% of cases for ointments and creams, and 23% for a solution, dryness and peeling of the skin – in 1-10% of cases for ointments and creams, and 1-5% of cases for the solution, erythema – 1 – 10% for the ointment, exacerbation of psoriasis (including the face and scalp) – 1-10% of cases for ointments and creams, and in 1-5% of cases for the solution; rarely (1% ointment for and the lack of effects for the cream and solution), skin atrophy, folliculitis, hyperpigmentation – in less than 1% of cases for ointments and creams, and the lack of effect for a solution, the systemic effects (usually asymptomatic, going alone). overdosage. Symptoms (more than 100 g of ointment or cream to 1 week): hypercalcemia, abdominal pain, constipation, depression, unusual fatigue, increased blood pressure, loss of appetite, weight loss, thirst, nausea, vomiting, and hypercalciuria. Treatment: discontinuation of the drug, the purpose of intensive hydration (oral and parenteral) of the body and forced diuresis (furosemide on the background to increase the rate of excretion of the drug), potassium chloride (to prevent hypokalemia), corticosteroids, hemodialysis (renal failure), the monitoring of electrolytes, control daily urine.
Dosage and administration Dovonex Cream:
Externally, an ointment or cream applied thinly to the affected areas 2 times a day (after the application of the drug should avoid wearing clothing compressing). The maximum daily dose – 15g, weekly – 100 g. The course of treatment for the cream should not exceed 6-8 weeks, the ointment – 1 year (in the absence of a long-term clinical trials). Solution is applied to the affected areas of the scalp two times a day and rub lightly. Weekly dose – 60 ml. If the solution is applied simultaneously with a cream or ointment, the total dose should not exceed 5 mg / week (60 ml and 30 g of cream or ointment, or 30 ml and 60 g of cream or ointment).
Special instructions Dovonex Cream:
Should not be applied to large areas of lesions (30% of skin surface) and on the skin. Not recommended for use on large skin surfaces, or in severe chronic psoriasis (due to the increase in the intensity of absorption and increase the risk of hypercalcemia). If you need to use in these forms of psoriasis, it requires careful monitoring of the concentration of Ca2 + in blood and urine. Treatment continues as needed depending on the effect, but not more than 1 year. Treatment can be combined with selective and PUVA phototherapy. That patients under age 18 may only short courses and on skin surface, not exceeding 30% of the total body surface, in the case where the appointment of other drugs does not lead to satisfactory results. Children are more vulnerable to manifestations of systemic effects than adults (because of their higher ratio of skin surface area to body weight). Systemic effects are usually reversible and offset of drug discontinuation. After applying to the affected area should wash your hands thoroughly to avoid getting the drug on the face, mucous membranes or skin healthy. Before treatment and regularly during therapy is recommended to monitor the concentration of Ca2 + in the blood. With the continuous long-term use of high doses can not completely exclude the risk of hypercalcemia and focal calcifications in the kidneys. Use the drug during pregnancy is not recommended due to lack of sufficient clinical data on the use of the drug in pregnant women. In animal experiments revealed fetotoksicheskie phenomenon: incomplete ossification of the pubic bones, the phalanges of the upper limbs, ribs, cleft fontanelle. It is not known whether calcipotriol is allocated in breast milk, so if you need to use during lactation should decide on the termination of breastfeeding.
Interaction Dovonex Cream:
Do not apply simultaneously with salicylic acid and preparations containing it.
